Human Cancer Biology Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant β-Catenin Activation in Colon Cancer
نویسندگان
چکیده
Differential Thymidylate Synthase Expression in Different Variants of Large-Cell Carcinoma of the Lung. Valentina Monica, Giorgio V. Scagliotti, Paolo Ceppi, Luisella Righi, Alberto Cambieri, Marco Lo Iacono, Silvia Saviozzi, Marco Volante, Silvia Novello, and Mauro Papotti ..................................................................................................................................7547
منابع مشابه
Inhibition of Vascular Endothelial Growth Factor Receptor-1/Wnt/ β-catenin Crosstalk Leads to Tumor Cell Death
In this issue of Clinical Cancer Research, Naik and colleagues (1) provide the rationale for a synthetic lethal therapy theoretically based on targeted inhibition of vascular endothelial growth factor receptor-1 (VEGFR1)-mediated kinase activity in Wnt/βcatenin-addicted human colorectal cancer (CRC) cells (Fig. 1). Wnt is a cysteine-rich secreted molecule and prototype of a 19-member family of ...
متن کاملCCR Translations Inhibition of Vascular Endothelial Growth Factor Receptor-1/Wnt/ β-catenin Crosstalk Leads to Tumor Cell Death
In this issue of Clinical Cancer Research, Naik and colleagues (1) provide the rationale for a synthetic lethal therapy theoretically based on targeted inhibition of vascular endothelial growth factor receptor-1 (VEGFR1)-mediated kinase activity in Wnt/βcatenin-addicted human colorectal cancer (CRC) cells (Fig. 1). Wnt is a cysteine-rich secreted molecule and prototype of a 19-member family of ...
متن کاملInhibition of Vascular Endothelial Growth Factor Receptor-1/Wnt/{beta}-catenin Crosstalk Leads to Tumor Cell Death.
Two genes are considered synthetic lethal if mutation of either alone allows cell viability, whereas simultaneous mutation leads to cell death. A synthetic lethal screen unveiled the dependency of Wnt/beta-catenin-addicted colorectal cancer cells on vascular endothelial growth factor receptor-1 kinase activity and suggested a novel therapeutic approach for this malignancy. (Clin Cancer Res 2009...
متن کامل-Catenin Regulates Vascular Endothelial Growth Factor Expression in Colon Cancer
To evaluate whether -catenin signaling has a role in the regulation of angiogenesis in colon cancer, a series of angiogenesis-related gene promoters was analyzed for -catenin/TCF binding sites. Strikingly, the gene promoter of human vascular endothelial growth factor (VEGF, or VEGF-A) contains seven consensus binding sites for -catenin/TCF. Analysis of laser capture microdissected human colon c...
متن کاملbeta-Catenin regulates vascular endothelial growth factor expression in colon cancer.
To evaluate whether beta-catenin signaling has a role in the regulation of angiogenesis in colon cancer, a series of angiogenesis-related gene promoters was analyzed for beta-catenin/TCF binding sites. Strikingly, the gene promoter of human vascular endothelial growth factor (VEGF, or VEGF-A) contains seven consensus binding sites for beta-catenin/TCF. Analysis of laser capture microdissected h...
متن کامل